Refissa is a prescription product coming from Spear Pharmaceuticals and Obagi at the same time. Over the counter, it generally sells for around $88, and they claim that it will be able to effectively speaking reduce your wrinkles by producing more collagen and elastin. They claim you can “see the difference between a fine line, a wrinkle, and a skin fold.
The problem is that their one active ingredient, tretinoin, does not produce more collagen and elastin. In fact, while they claim it corrects irregular pigmentation, tretinoin has been known to cause irregular hyperpigmentation! Ironically, while claiming to reverse sun damage and protect from it, tretinoin also causes greater sensitivity to the sun. There are quite a few contradictions, right?
Anyway, the thing about this is that it works by turning over skin cells, hopefully thickening skin and washing away dead skin cells. This being said, it can cause quite a few different side effects, and it doesn’t really necessarily give you any results. Some early studies have suggested that tretinoin may reduce fine lines. But there is nothing about wrinkles or eliminating any of these problems.
We would not recommend Refissa. They need to seriously rethink their advertising. Being a prescription approved by the FDA, it does not make them exempt from fair rules of correct advertising. In fact, it should hold them to a more stringent standard. But obviously it does not, or at least not so far. We would highly recommend finding something else.